Pyrophoric Material Dispensing System Enhance product safety and prevent release during transfer operations. Perfect for professionals looking for a containment tool box. The potency of...
Read MoreRABS
(Restricted Access Barrier System)
For Aseptic Processing & Fill-Finish Operations
Restricted Access Barrier Systems (RABS) provide an advanced solution for pharmaceutical aseptic processing, sterile filling, and capping operations. Combining rigid wall construction with controlled airflow, RABS create a Grade A / ISO 5 environment that minimizes contamination risk while improving flexibility and cost-efficiency compared to traditional cleanrooms or isolators.
A RABS is a semi-enclosed aseptic barrier system designed to separate operators from sterile product zones during pharmaceutical manufacturing. By using rigid transparent panels, glove ports, and integrated HEPA filtration, RABS maintain unidirectional airflow and minimize operator intervention into the critical fill-finish zone.
This physical and aerodynamic separation helps reduce contamination risks associated with open cleanrooms or laminar airflow systems, while providing a scalable solution for facilities that require high-level aseptic control without the full infrastructure of an isolator system.
Types of RABS Systems
RABS systems are available in two primary configurations, depending on facility requirements:
Open RABS (Active or Passive)
- Controlled airflow with air returning to the cleanroom through engineered gaps.
- Easier retrofitting into existing fill-finish lines.
- Requires classified background cleanroom environment.
Closed RABS (Active or Passive)
- Fully enclosed design with controlled internal pressure.
- Offers enhanced containment and sterility control.
- Still requires cleanroom background but with greater protection for high-risk operations.
Ideal RABS Applications
- Pharmaceutical fill-finish operations
- Vaccine manufacturing lines
- Biologics and sterile injectable production
- Contract manufacturing and multi-product facilities
- Cleanroom retrofits and facility upgrades
- Small to medium-scale aseptic operations
Benefits of RABS for Pharmaceutical Manufacturing
Cost -Effective Cleanroom Upgrade
RABS allow pharmaceutical and biotech manufacturers to upgrade existing fill-finish lines to modern aseptic standards without the need for complete cleanroom rebuilds or full isolator installations.
Advanced Contamination Control
With rigid barriers, glove ports, and HEPA-filtered airflow directly over the filling line, RABS provide nearly isolator-level protection while still allowing occasional operator interventions under controlled conditions.
Flexibility for Multi-Product Manufacturing
RABS systems are ideal for contract manufacturing organizations (CMOs), multi-product production lines, or facilities producing small-batch vaccines, biologics, or injectables—allowing for faster changeovers and adaptable production formats.
Lower Capital and Operating Costs
Compared to full isolators and complete cleanroom renovations, RABS offer reduced HVAC demands, lower capital investment, and long-term operational cost savings—all while meeting stringent aseptic processing requirements.
Ergonomic Design & Operator Safety
Our RABS systems are engineered with both operator ergonomics and process integrity in mind. Operators have full access to the system through doors during setup and preparation. Once production begins, all adjustments and fine-tuning are performed through glove ports, reducing risk of contamination while maintaining production efficiency.
Each unit features HEPA-filtered ceiling plenums, fully DOP-testable filters for certification, integrated environmental monitoring, alarms, and customizable controls to meet your exact process specifications.
Optimize Your Aseptic Processing with RABS Technology
Whether you’re upgrading an existing cleanroom or designing a new fill-finish line, our custom RABS solutions deliver flexible, validated, and cost-effective aseptic processing—built for compliance and performance.